Drug vs. Drug

Trintellix vs Lexapro: Main Differences and Similarities

By | June 25, 2019

Trintellix (vortioxetine) and Lexapro (escitalopram) are two antidepressant medications that can treat depression or, more specifically, major depressive disorder (MDD). Lexapro can also treat anxiety disorders with less sexual side effects. As selective serotonin reuptake inhibitors (SSRI) type medications, Trintellix and Lexapro work to regulate serotonin in the brain. However, there are still some differences in how they are used.


Trintellix is also known by its chemical name, vortioxetine. Approved in 2013, Trintillex can treat MDD in adults. There is currently no generic version available yet.

Trintellix comes as a 5 mg, 10 mg, or 20 mg oral tablet. It can be taken once daily with or without food. Trintellix has a half-life of a few days and, unlike other SSRIs, can be discontinued abruptly.


Lexapro is the brand name for escitalopram. It was approved in 2002 to treat MDD in adults and adolescents aged 12 to 17 years old. Lexapro can also treat generalized anxiety disorder (GAD).

Lexapro is available in generic oral tablets with strengths of 5 mg, 10 mg, or 20 mg. It can be taken once daily with or without food and has a half-life of almost 2 days. Additionally, the dose must be reduced over time if the medication is being discontinued.

Trintellix vs Lexapro Side by Side Comparison

Trintellix and Lexapro are antidepressants that can treat similar conditions. Their main features and differences can be found below.

Trintellix Lexapro
Prescribed For
  • Major Depressive Disorder (MDD)
  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
Drug Classification
  • Selective Serotonin Reuptake Inhibitor (SSRI)
  • Selective Serotonin Reuptake Inhibitor (SSRI)
Common Side Effects
  • Nausea
  • Dizziness
  • Diarrhea
  • Insomnia
  • Abnormal dreams
  • Constipation
  • Vomiting
  • Dry mouth
  • Indigestion
  • Pruritus
  • Nausea
  • Dizziness
  • Diarrhea
  • Insomnia
  • Fatigue
  • Indigestion
  • Headache
  • Agitation
  • Shaking
  • Somnolence
  • Increased sweating
  • Decreased libido
  • Ejaculation Disorder
  • Anorgasmia
Is there a generic?
  • There is no generic currently available
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral tablet
  • Oral tablet
  • Oral solution
Average Cash Price
  • $426 for a supply of 30, 10 mg tablets.
  • $379 for a supply of 30 tablets, 10 mg
SingleCare Discount Price
Drug Interactions
  • MAO inhibitors (isocarboxazid, phenelzine, selegiline, tranylcypromine)
  • CYP2D6 inhibitors (fluoxetine, paroxetine, etc.)
  • Other SSRIs
  • SNRIs
  • Triptans
  • Tricyclic antidepressants (amitriptyline, nortriptyline, imipramine)
  • Opioids
  • Lithium
  • Tramadol
  • Buspirone
  • St. John’s Wort
  • NSAIDs
  • Aspirin
  • Warfarin
  • Phenytoin
  • Carbamazepine
  • MAO inhibitors (isocarboxazid, phenelzine, selegiline, etc.)
  • Tricyclic antidepressants (amitriptyline, desipramine, doxepin, etc.)
  • Other SSRIs (citalopram, fluoxetine, sertraline, etc.)
  • SNRIs (duloxetine, venlafaxine, etc.)
  • Triptans (almotriptan, rizatriptan, sumatriptan, etc.)
  • Amphetamines (dextroamphetamine, levoamphetamine, lisdexamfetamine, etc.)
  • NSAIDs (celecoxib, etodolac, ibuprofen, aspirin etc.)
  • Warfarin
  • Pimozide
  • Buspirone
  • Cimetidine
  • Lamotrigine
  • Phenytoin
  • Carbamazepine
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Trintellix is in Pregnancy Category C. Adequate studies have not been performed in humans. Consult a doctor regarding steps to take while pregnant and breastfeeding
  • Lexapro is Pregnancy Category C. Animal studies have shown adverse effects to the fetus. Adequate studies have not been performed in humans. Lexapro is not expected to harm breastfed infants. Consult a doctor regarding steps to take while pregnant and breastfeeding


Trintellix (vortioxetine) and Lexapro (escitalopram) are brand-name SSRI type medications that can treat depression as MDD. Both medications are taken once daily depending on a doctor’s instructions. Lexapro can also treat anxiety.

Trintellix and Lexapro can be taken with or without food. While they have similar side effects such as nausea and dizziness, these side effects usually go away after consistent use. Trintellix is known to cause less sexual side effects than other SSRIs. Therefore, it is a better alternative for those who suffer from libido problems with other antidepressants.